If I was buying a rifle just for predators I'd probably get one of three --- .223, .22-250, or .204. That said I deer hunt mostly with a .243 and shot my first one with it this year. Shot it with 100 grain Remington Core Lokts at 69 yards. Went it like a pencil hole and blew out the opposite side in about a 5" diameter. Picked it up and body slammed it like nothing. If you don't want to do anything with the hide it's perfect. Otherwise shoot a smaller bullet.