Depends on where I'm hunting. If on the edge of a swamp, really thick stuff, or high ridges I try the shoulder shot to anchor them on the spot. Sometimes under those same circumstances (and I don't recommend this shot for everyone), if I don't have the shoulder shot I'm not bashful about a spine shot. I've killed several bucks with that being the only shot that presented itself. Otherwise I like seeing them make that death rush and I like following a blood trail thus the heart/lung shot.