Both are nice rigs and the 22-250 is a HOT round (50gr VMAX @4000fps box stock @4250+ handloaded)and will flat out shoot em dead, however i prefer a .223 and little lower power scope. I have been addicted to coyotes for several years now and have tried several setups from unethical anemic .17hmr to screaming hot .243 (65gr VMAX @ 4075FPS)and have found the most effective rig is Stevens 200 in .223 with old bushnell 2.5X7X36 running 77gr Nosler Custom Competition. Lite enuff to haul around allday great wide sight picture on low power and cheap to shoot and heavy enuff bullet to punch through tall grass and lite brush. when i got started i thought i would need a flat bullet that could shoot out to 500 yards but found that in tennessee most of my opportunities (notice i said opportunities not shots) came from within 100 yards and were only present for very few moments, so i need a rig to be faster and accurate and lite recoil so i could stay on target. i will say this...my opnion is my personal prefrence...the best advice i can offer is get what you want and learn how to run it effectively and accuratly and have fun....having one come blazing into your call is one of the greatest adreneline rushes you can have while hunting. Good Luck