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I've only killed one deer some years back with a 308 and that was with the plain jane 150 gr. Federal Classic loads. It did a fine job though with complete penetration through the chest cavity and spray all over the grass 20 feet beyond. The little buck ran maybe 20 feet and dropped. I've shot 308s a lot and always liked the 168 match bullets for playing around with targets but that's the only deer I ever shot with one. I just recently bought another one and have been playing with the target loads again. If I wanted to use it for hunting the 165 Nosler Ballistic tips usually shoot about the same as the 168 Hornady or Sierras.