I very seldom catch stripers on artificial lures. By far my biggest ones have came on live gizzard shad and or skipjack. But I have caught some on spoons and topwater/wake bait (redfin). And the upper Watts Bar area is my favorite area for them. From Pole Cat on down river a ways. Gotta have current.
Earlier in the spring I caught a nice one on an umbrella rig. Don't know if that will work well this time of year. Trick is experimenting with different retrieval speeds, letting it sink at different times (sometimes reeling as soon as it hits the water is best, sometimes letting it sink is---either way, chances are good you'll be making quite a few casts, so have a good long casting rod to save you from too much fatigue).