The only snakes aggressive enough to actually come after me were moccasins in the Green Swamp of Florida.
They can be very aggressive at times.
I've several times experienced them aggressively coming to me, and have had to kill a couple truly in self defense. Most of my experiences with them have been while fishing around the back-waters of the Mississippi River (West KY & West TN) and around Reelfoot Lake.
A few years ago, while October bowhunting near the Mississippi, one of the largest cottonmouths I've ever seen struck me right above the ankle. Fortunately I was wearing snake boots on top of my stocking foot waders. I was walking thru some sycamore leaves, no where near any water. I stepped on a big one, jumped back trying to decide the next step, when I stepped backwards & sideways, a different & bigger one struck me. Both quickly disappeared under the sycamore leaves, and I went on my way.