Springfield XD or maybe a Glock. Anytime you purchase a gun for self defense purposes you want to spend all that you can afford and get a quality firearm that will cycle 100% of the time. These two are the only ones I can think of that will fire and function no matter what (within reason). I own an XD in .357 Sig, and would probably own a Glock if it weren't for that high grip angle. My conceald gun is a 2 inch barreled "Carry it Anywhere" series Taurus in .357 mag, them and the S&W's are great if you like a revolver. I have heard to stay away from any Taurus auto. My $.02.