Different stand locations for different times of the fall. Coming up in November and on into December, I will exclusively hunt certain terrain features and pinch-points with some thick cover. That is where I have had the best luck during all phases of the rut. During bow season and late season, I gear more towards food sources. Though, during the phases of the rut, I will not just specifically hunt terrain features in general, but also terrain features that lead to a food plot (where I know the does are likely to be heading towards). Some of these thicker transition areas within 200 yards of prime food sources can be VERY effective!
This year, I have saved all my lock-ons for muzzleloader and rifle....and I guess choosing one of them for a particular morning, I first look at the wind, second see if I can get there with the right approach with that particular wind, then it all comes down to that "gut feeling" as TNTom mentioned.