I know many disagree with me, and the fad seems to be using "lighter" or smaller calibers,
but each year I'm asked to help find deer that others make marginal and/or bad hits on with these smaller calibers,
and they often run long distances after being hit.
With a good hit, you can kill one with a .22 rimfire.
It's just that we often are not the marksmen we aspire to be.
I do most of my rifle deer hunting with a .300 Weatherby.
Over kill, perhaps, but bad shoots still usually result in my recovering the deer near where he was hit.