A few years ago the TWRA did some pretty intense testing and found none in the state. But if it's in VA and AR, it will come to TN soon.
When it gets here it won't change the way I hunt, but it will change the way I manage (much higher natural mortality rates, and doing nothing that can concentrate deer at a particular spot, like feeding or salt licks).
Luckily, so far, no human has gotten Creutzfeldt–Jakob Disease (CJD) from eating or handling a CWD infected deer, unlike those infected by eating cattle infected with Mad Cow Disease (MCD). But I would certainly be extra careful not to cut through spinal or brain tissue while processing meat.