I've killed a pile of deer with a bow out of a ladder stand. It all depends on how you set it up, your available cover and how high you go.
I have several climbing sticks with loc-ons and I have several ladders all over my farms. I like both. When videoing with my son, I like to use a ladder and I will just hang a loc-on above it. It's easier for him to get in and out of and just makes me feel better when he's climbing up. When I need to hang a stand and I don't have any help, I will hang a ladder and a loc on. I will hunt those stands myself or put an adult guest in them.
I set up 2 ladders today with my Dad. I start with a 15' ladder from Dicks and then add the 4' extension. That gets the platform to about 18' because the 15' is measured at the seat. Then, I use any elevation to my advantage and can usually get 2-8 more feet from that. I always try to pick a tree with cover, a fork, split trunk, etc.
One thing I do on ALL my stands is install a 30' climbing system with a prusic knot. That way, you can stay hooked up from the time you leave the ground. I learned the hard way 7 years ago when I fell 17'. Trust me, use a climbing system and a good harness. Worth every penny!