Depends on what you are hunting and the results you want.
150gr factory rounds routinely blew deer half apart at close range. LOTS of bloodshot meat.
Went to a hornady innerlock 162gr BTSP over IMR4350 and am getting approx 2900fps. Good balance between penetration and expansion at all ranges. Blood shot is now more of a softball size.
Prior to using a heavier bullet and "loading down" I would get a basket ball sized blood shot and usually ruin both shoulders and a section of backstrap even when I put it through the ribs just behind the shoulder.
After I got over the "WOW"! I blew up a deer factor, decided to find something with better overall performance.
The 162gr is a great all around hunting round. Penetration for elk and hogs, good expansion on deer without blowing them half apart.