The handgun you chose is going to be the limiting factor for pressure of the ammo. You really need to handload to achieve the utility this cartridge is capable of. Although I prefer the Colt Single Action's purely from an aesthetic point of view, probably the most practical gun choice would be a Ruger Blackhawk. Reason being that they have good adjustable sights and are stronger guns. You can easily load them up to achieve 1000 ft-sec using a 260 grain lead bullet. You can do this with the Colts or Colt copies but you are pushing them closer to their limits and the vast majority of Colts or their clones don't have adjustable sights. The only Colts with adjustable sights are the New Frontier models and they are going to cost you at least $1,500! Anyhow, if you were to start handloading, and did go the Ruger Blackhawk route so that you could get 1,000 to 1,100 ft-sec out of the handgun, then a Winchester or Henry lever action rifle should get another 150 to 200 ft-sec out of the same load and you'd be set to hunt deer just fine in thickets.