I will second all that 348Winchester said, in addition to H335 being good for the 45/70 levergun loads, and I have heard of some people having success out of Varget. I know that the H335 was known for having a high level of muzzle flash in this cartridge. When I had a 45/70 I used RL7, Unique, and 2400, but have heard that the two flavors of 4198 are equally as good as the RL7. I used the 2400 for midrange loads, and the Unique for "mouse fart" loads that any woman or kid could shoot. I know that my Marlin Guide Gun with 320 and 420gr cast bullets ahead of RL7 was the cat's pajamas on anything from deer to toothy critters, although I only used it on the former. Also, I loved the Starline brass for the 45/70, if it matters.