Depends on your rifle. If you hand load, you can tweak it for best results so you don't really lose much if any. I think the optimal bullet weight is based on the rate of twist of your rifling. I have a rem700 in 300 win mag. I think the optimal bullet weight for mine and most other manufacturers is 180gr. Remington also makes a police sniper version of the 700 in 300 win mag with a different rate of twist so that it can shoot heavier bullets more accurately.