When I started shooting the Savage 50 several years ago, AA5744 was the first powder I tried. Got the gun zeroed and grouping decent with Hornady 4500 300gr hollow points and crush ribs.
Opening day of ml it was near 45 degrees. Killed a doe no problem. 4 days later went to same spot. Temp around 32 degrees. Shot a buck that was nearly in the same spot. (I was in a ground blind with a deadshot field pod) The buck stood there looking around so I started reloading but by the time I was done, he had meandered behind some trees.
The next week I went to the range. Got there and it was around freezing. Fired the shot and was 8 inches high. Put the gun aside and shot others. As the morning warned up, I shot it again at about 40 degrees and was only 4 inches high. I waited until it was around 50 degrees and fired another shot that was 1 inch high right where I had zeroed it. I fired another 1" 3 shot group.
I started researching after that and found that AA5744 has 15 to 20 percent nitro. I found that when subjected to freezing temps, nitro crystallizes. When this happens, the burn rate is altered, causing it to burn at a much faster rate.
Since that day, I switched to Reloder 7 and enjoyed accuracy, speed and reliability. YMMV but I lived it. Good luck.