Food for thought...APAP toxicity (Tylenol)

[Speedwell-Hunter]

Healthcare workers estimate that around 500 people in the USA die yearly of Tylenol (APAP also called Acetaminophen) EVERY YEAR!

Reportedly also Tylenol causes:
- 100,000 calls to US Poison Control Centers yearly
-50,000 emergency room visits
-10,000 hospitalizations per year

If overdose is identified early enough, mortality rates are extremely low. However, once acute liver failure has developed, mortality is approximately 28 percent, and a third of patients require liver transplantation.

A national network established in 1998 to track cases of acute liver failure in the United States found that nearly half the episodes of acute liver failure are attributable to acetaminophen.


Ban Tylenol?

Source:

Public Health: Acetaminophen (APAP) Hepatotoxicity—Isn't It Time for APAP to Go Away?

Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, ...

www.ncbi.nlm.nih.gov

 

[backyardtndeer]

There are also lawsuits against Tylenol for links to autism.

 

[7mm08]

Anything over 4 grams (4,000 mg ) a day TOTAL is toxic to your liver.

 

[Kimber45]

Wonder if they can guesstimate how many lives might have been saved when used correctly to control what would have been dangerously high fever.…

 

[ROB]

Sadly, there have been cases where people took a bunch of Tylenol as a suicidal gesture, not so much to kill themselves as to get attention. After getting that attention, they no longer want to kill themselves but their liver starts to shut down & they end up dying a horrible death.

 

[Bamamonts]

My wife always tells me not to take it for headaches because it’s bad for your liver. Maybe I should listen.

 

[TNGunsmoke]

I alternate with ibuprofen. Wish my wife would listen about taking too much of it, but she's hard headed.

 

[Speedwell-Hunter]

Anything over 4 grams (4,000 mg ) a day TOTAL is toxic to your liver.

Correct; give or take

In alcoholics , much less (and they typically do not know it) due to damage to the cytochrome p450 enzymes from drinking.

 

[TAFKAP]

I lost a friend to liver failure in college......combining alcohol and Tylenol is a very toxic mixture that many people aren't aware of. Someone mentioned above how horrible of a death it is. My buddy died when his liver failure caused his kidneys to shut down. In his convulsing, he broke his own nose and drowned in the blood when it filled his lungs.

If you drink, especially if you drink a lot, you should be very mindful about taking Tylenol. If you have alcohol/Tylenol within 4 hours, don't introduce the other one to your system. If you're hungover, take Aleve. If you've been controlling pain/fever with Tylenol, skip the drinks for a while.

The best way to control a fever if you don't have any allergies is to alternate 800mg (maximum) doses of acetaminophen with 800mg (maximum) doses of ibuprofen. Both offer fever control benefits, and both are long term dangerous to the liver. But alternating will help manage fever, and will reduce the stomach issues.

8:00am Start with two ibuprofen
noon take two Tylenol
4:00pm two ibuprofen
8:00pm two Tylenol

This spreads out your allowable max dose across the day, while time-lapse controling the fever.

 

[7mm08]

Correct; give or take

In alcoholics , much less (and they typically do not know it) due to damage to the cytochrome p450 enzymes from drinking.

Now you done it! Talking about the cytochrome p450 enzyme and all its party friends causing drug/ drug interactions.

 

[redblood]

I alternate with ibuprofen. Wish my wife would listen about taking too much of it, but she's hard headed.

i think ibuprofen kills your kidneys- pick your poison i guess. my inlaws are alcoholics ( and she is a registered nurse). she says if you drink at all, take ibuprofen because of the damage the alcohol does to liver as well

 

[Speedwell-Hunter]

i think ibuprofen kills your kidneys- pick your poison i guess. my inlaws are alcoholics ( and she is a registered nurse). she says if you drink at all, take ibuprofen because of the damage the alcohol does to liver as well

Yep

It constricts blood vessels in the juxta glom apparatus leading to less blood flow and then injury!

 

[redblood]

So question for 7mm08

what is the safest OTC painkiller. i take very little because my joints and backs are pretty good. But for headache i generally go tylenol. some folks swear by naproxen, and a few i know still use aspirin

 

[Kimber45]

I took an ibuprofen maybe a few times a week until heart stents. Cardiologist said absolutely NO MORE ibuprofen products, so 0 ibuprofen now in 4 years.. and Tylenol ONLY if I have fever.

 

[DaveTN]

Acetaminophen is a big problem with prescription pain killers like hydrocodone.

 

[iowavf]

When my knee gets inflamed, doctor said take an Aleve.

 

[backyardtndeer]

Acetaminophen is a big problem with prescription pain killers like hydrocodone.

Hydrocodone contains acetaminophen(Tylenol).

 

[DaveTN]

Hydrocodone contains acetaminophen(Tylenol).

Yes. Thats what I posted.

 

[7mm08]

My heel is killing me from standing all day….. I just chucked down 1000mg Tylenol and 600 mg of Ibuprofen. That will fix my ills. My kidney and liver functions are normal ( at least 2 months ago when I had my physical) and I don’t do it everyday.

All meds have an effect and side effect. Follow the instructions on the box and try to avoid long term use of these meds. Short term pain med … Tylenol for me. I use to eat Motrin because of my knee and back from bending over all day in the OR. SINCE retiring and unfortunately getting a total knee replacement I rarely take Motrin or Aleve. Maybe because I tried RELIEF FACTOR now and I think it helps some with my usual aches and pains.

Ask your healthcare provider what is good for you.

 

[backyardtndeer]

Maybe because I tried RELIEF FACTOR now and I think it helps some with my usual aches and pains.

Sebastian Gorka says it works. lol. Wondered if it really works. I think it has omega-3 in it.