My son used a 240 gr Hornady XTP Mag (Thompson Center version) with two 50 gr 777 pellets to get complete passthru and heavy bloodtrail on a nice doe at 45 yards. I used 300 gr Hornady XTP mag with 110 gr 777 loose to take a 1.5 yr old buck at 70 yards, also complete passthru with very heavy bloodtrail. Both exit holes were close to size of entrance holes, but they were rib shots that hit no heavy bone.

Both rifles are CVA Optima (non-fluted version).
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It's not rocket surgery, for crying outside!